pHARMACEUTICAL ORTHOPAEDIC RESEARCH LAB - University of Alberta


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Our Facilities

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MicroCT suite
Two MicroCT,SkyScan 1076 &1176, instruments are install-ed in the PORL MicroCT lab. Both are available for in-vivo scans.
PORL Lab
PORL Lab
More than 20 instruments, eq-uipped with a Bacterial Shaker Room and a Cell Culture Room.
Software Software
Software
A series of imaging processing software from SkyScan; Mimcis for image segmentation and ABAQUS for mechanics analysis of bone.
faculty infrastructure Faculty Infracture
Faculty Infrastructure for Pharmaceutical Analysis
Mass Spectrometer & NMR (Nuclear Magnetic Resonance) Spectrometer

MicroCT suite

High resolution micro-CT imaging has arrived at the University of Alberta Campus! 

Thanks to Federal funding from the Canada Foundation for Innovation (CFI), the PORL has successfully established Edmonton’s first “in-vivo” micro-CT Imaging Suite at the University of Alberta, to non-invasively quantify bone and mineral adaptations after pharmaceutical, orthopaedic, orthodontic and biomedical interventions.

With the advent of high-resolution micro-CT at this University, collaborative research has begun between The Faculty of Pharmacy & Pharmaceutical Sciences and many disparate faculties on this campus, including Chemical & Materials Engineering, Biomedical Engineering, Medicine & Dentistry, and Electrical & Computer Engineering.

The Pharmacy micro-CT imager is the first of its kind in Edmonton, and has enabled us to measure the efficacy of newly discovered bone drugs non-invasively, and over several months to help identify drug candidates with the greatest therapeutic benefit using the most appropriate regimen.


Model

SkyScan 1076

SkyScan 1176

scan

In-vivo /ex-vivo

In-vivo/ex-vivo

X-ray Source

sealed X-ray tube 20-100kV, spot size <5µm, 10W

90kV X-ray source

X-ray Detector

4000x2672pixels, 12bit, fiber-optically coupled to scintillator

4000x2672pixels, 12bit, fiber-optically coupled to scintillator

Scan Volume

68mm diam., 20mm(suggested 14mm) single scan length, 200mm scannable length

68mm diam., 20mm single scan length, 200mm scannable length

Spatial Resolution

<9µm pixel size, <15µm low-contrast resolution (10%MTF)

<9µm pixel size, <15µm low-contrast resolution (10%MTF)

Reconstruction Slices

9µm/18µm/35µm selectable pixel size

9µm/18µm/35µm selectable pixel size

Gating

breathing, heartbeat etc.

breathing, heartbeat..etc.

In-vivo animal scan

Rats, mouse..

Available for larger animal.,e.g. chicken, rabbit..

Services for

Industries (contact OMX Inc.)

Academics


PORL Lab Room 2-108

There are more than 20 professional instruments in the main lab of PORL. Besides, a Cell Culture room and Bacterial Shaker Room are also well installed.

PORL Lab Room


Description: D:\PORL\facilities\instrument\Alpha Innotech Corporation Multiimage Light Cabinet With Camera & Filters2.JPG

Description: D:\PORL\facilities\instrument\BIO-TEK EL808-Microplate Reader(Elisa Reader;Luminometer).JPG

Description: D:\PORL\facilities\instrument\Buehler-IsoMet® 1000-Sawing Machine, .JPG

Alpha Innotech Corporation Multiimage Light Cabinet With Camera & Filters

BIO-TEK,EL808-Microplate Reader(Elisa Reader; Luminometer)

Buehler-IsoMet®1000-Sawing Machine

Description: D:\PORL\facilities\instrument\Cole-Parmer Polystat- Stainless Steel Heated Bath.JPG

Waters600S

Description: D:\PORL\facilities\instrument\Eppendorf Mastercycler® ep Thermal Cyclers-PCR research.JPG

Cole-Parmer Polystat- Stainless Steel Heated Bath

Waters 600S-HPLC

Eppendorf Mastercycler® ep Thermal Cyclers-PCR research

Description: D:\PORL\facilities\instrument\Fisher Scientific-accume AB15- pH-mV-C Meters .JPG

Description: D:\PORL\facilities\instrument\Forma-Series II 3110-Water-Jacketed CO2 Incubators.JPG

Description: D:\PORL\facilities\instrument\Instron4443-Material Testing System.JPG

Fisher Scientific-accume AB15- pH-mV-C Meters

Forma-Series II 3110-Water-Jacketed CO2 Incubators

Instron4443-Material Testing System

Description: D:\PORL\facilities\instrument\Lab-Tek - REICHERTJUNG BIOCUT 1130-ROTARY MICROTOME.JPG

Description: D:\PORL\facilities\instrument\SANYO-MPR-414F 14.9 cu. ft.- Pharmaceutical Refrigerator with Freezer.JPG

Description: D:\PORL\facilities\instrument\Sorvall Legend RT-Refrigerated Table Top Centrifuge.JPG

Lab-Tek - REICHERTJUNG BIOCUT 1130-ROTARY MICROTOME

SANYO-MPR-414F,14.9cu.ft.- Pharmaceutical Refrigerator with Freezer

Sorvall Legend RT-Refrigerated Table Top Centrifuge


Software

Our microCT suties are equipped with a series of imaging processing software from SkyScan.

Function Program (SkyScan)
Reconstruction Server Nrecon Server
Reconstruction Nrecon
Image Analysis CTAn
3 planes view of images DataViewer
3Dimensional Viewing CTVol
3Dimensional Viewing CTvox
Batch Job Processing BatMan

 

Besides of those commercial softwares from SkyScan(Konitch,Belgium), PORL also has the latest version of Mimics (Materilise, Luven, Belgium) for imaging segmentations and 3 dimensional modeling for Finite Element Analysis.

PORL also cooperates with Dr. Samer Adeeb in Civil Engineering to have the resource of ABAQUS (SIMULIA, Providence RI) for finite element analysis on biomechanics.


Faculty Infrastructure for Pharmaceutical Analysis

Mass Spectrometer

Mass Spectrometer

Waters 2795-Mass Spectrometer-Ionization and fragmentation of a molecule in a magnetic field

NMR

NMR

NMR(Nuclear Magnetic Resonance) Spectrometer-Identifies the composition of a molecule based on nuclear spin

 


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ResultsGallery

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Exciting Images from our MicroCT Imagers. (SkyScan 1076/1176)
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